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The European Society of Anaesthesiology guidelines for the management of perioperative bleeding state that "adequate TEG® Functional Fibrinogen test/FIBTEM clot strength in the presence of decreased overall clot strength in bleeding patients may indicate platelet deficiency," although specific thresholds for administering platelets are not provided.
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Increased MPV and PDW may indicate enhanced platelet activation in CSU, which is in contrast with previous observation regarding the systemic release of platelet factor 4 and beta-thromboglobulin, the indices of platelet activation [ 18], and in agreement with the study by Chandrashekar et al. [ 21].
This may indicate that canine platelet gel from PC activated with either CG or CGB produces only fibrin fibers of higher quality compared with other species (Pretorius et al. [ 14] used thrombin as an activating substance).
This may indicate that not only platelet count, but also platelet function must be taken into consideration [ 32].
This may indicate that the circulating platelet mass may need to become saturated with exogenously administered endostatin before it is able to target endothelial cells.
Moreover, a decrease in platelet count may indicate ongoing coagulation activation, which contributes to microvascular failure and organ dysfunction.
This may stem from the involvement of glycoprotein (GP) Ibα in thrombin [23] but not TRAP (which is PAR-1 specific) induced platelet activation and may indicate a role for PECAM-1 in mediating the action of GPIbα during thrombin stimulation of platelets.
We agree that the similar P-selectin levels in the patients that were on aspirin therapy may indicate aspirin resistance, although we did not assess platelet function directly and the group of patients on aspirin was small.
Although the activation step was very brief, this may indicate a tendency towards diversification of the exported proteome in response to platelet activation.
MA values, however, showed continuous reduction over time, which may indicate the fibrinolytic effects of CAPE [ 34] because MA is a function of both fibrin and platelet dynamic properties.
This may indicate difficulty concentrating.
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