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Repeats that remain conserved over micro- or macroevolutionary timescales despite such risks may indicate functionally or structurally (e.g., for replication) important regions.
A number of smaller clusters existed within these three large super-clusters that may indicate functionally related sets of genes.
Like highly conserved amino acids, variable positions under diversifying selection may indicate functionally or structurally important positions.
However, our results strongly suggest that using combined sCAIX and tumour Ki67 expression, to account for hypoxia-independent CAIX expression, could lead to the development of a cost-effective and clinically feasible test to efficiently identify patients with unfavourable outcomes that may indicate functionally hypoxic tumours.
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Given the role of CCR2 in DC chemotaxis and in DC-elicited Th1 differentiation, our results may indicate a functionally important DC abnormality in T1D affecting the initiation and quality of immune responses.
Increased gene variability may be relevant to particular diseases but also may be indicative of read alignment issues (often due the presence of gene duplicates) or may indicate the gene is functionally redundant and thus not functionally constrained.
On the other hand, the divergence in motif composition among different classes may indicate that they are functionally diversified.
The significant change in expression level of a miRNA observed between drought-treated and control samples may indicate miRNAs that are functionally responsive towards drought stress.
However, the presence of wild-type protein may indicate that p53 is functionally inactive because of alterations in the pathways that lead to its activation.
The marked reduction in the amplitude of rhythms in downstream tissues may indicate that there are functionally important outputs from both SCN compartments, with the SCN shell setting the phase of downstream tissues and the SCN core influencing amplitude.
That latter result may indicate that the strain 297 OspE protein is functionally different from the paralogous CRASP-3 and CRASP-5 proteins of strain B31.
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CEO of Professional Science Editing for Scientists @ prosciediting.com