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Increased MUC13 expression has been found to induce morphological changes, including scattering of cells through interference with the function of cell adhesion molecules [14]; thus, an increased expression along with differentiation may indicate enhanced cell-cell adhesion.
The dramatic up-regulation of TNFSF10 in the presence of LH may indicate enhanced apoptosis.
Increased circulation of kynurenine and KYN/TRP following regular black tea consumption may indicate enhanced tryptophan breakdown, possibly due to immune activation-induced tryptophan degrading enzyme indoleamine 2,3-dioxygenase.
In summary, we have demonstrated that the high BAG-1 expression is associated with the luminal A phenotype, is an independent predictor of outcome and may indicate enhanced responsiveness to tamoxifen in ER+ invasive ductal carcinoma.
Increased MPV and PDW may indicate enhanced platelet activation in CSU, which is in contrast with previous observation regarding the systemic release of platelet factor 4 and beta-thromboglobulin, the indices of platelet activation [ 18], and in agreement with the study by Chandrashekar et al. [ 21].
In a parallel in vivo experiment we detected a nearly three-fold increase in the expression level of Lox1 gene in isolated microvessels from transgenic mouse brains using qPCR, which may indicate enhanced transport of lipoproteins into the cells of the BBB (Lénárt et al. 2015 unpublished).
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This later fact is a likely reason behind the inconsistency between RASSF5A expression in tumor cells and its role as a tumor suppressor, as high levels may indicate enhance protein acetylation and inactivation of the ability to promote apoptosis of tumor cells.
The increase in self-sustained growth observed in Sum102 cells with TFPI downregulated may also indicate enhanced metastatic growth of these cells.
Increased conversion rates may also indicate enhanced metabolic activity of cells, which does not always correlate with an increase in proliferation [ 25, 26].
An increased contraction rate and longer inter-birth intervals indicate enhanced straining which may reflect greater pain during parturition [ 15].
These differences in B lymphocyte profiles may indicate an enhanced ability of the KO mice to cope with insults on their immune system (e.g. opportunistic infections), and thus may account for reduced perinatal lethality at week-3 and overall less severe phenotype compared to the Tg strains.
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