More permissive alignment algorithms may also reduce the proportion of fragments that cannot be aligned, but could increase spurious alignments in complex genomes such as maize.
Indeed, we have recently shown in mice that standardization may increase the incidence of spurious results in behavioral tests, accounting for poor reproducibility between replicate experiments, while systematic variation of experimental conditions (heterogenization) attenuated spurious results, thereby improving reproducibility [32].
Although reusing such existing data seems to be an efficient approach, it may increase chances of observing spurious associations due to chip differences.
When analysing smaller subgroups subsequent to the principal analysis the chance of spurious findings may increase.
This may increase the risk of reporting spurious results or associations that occurred by chance.
Moreover, inadequate reporting of statistical analysis information may increase the likelihood of publishing spurious associations or predictions.
Our analysis was not adjusted for multiple comparisons, which may increase the likelihood of observing spurious statistically significant differences between switchers and continuers (i.e., false positives).
However, the fact that there is no direct laboratory evidence on the function of the COX-2.8473 polymorphism may increase the likelihood of a spurious association or indicate the presence of some other functional SNPs in strong linkage disequilibrium with this SNP.
However, by increasing the number of grid points the computational time may increase considerably, while one-dimensional high-resolution difference schemes may generate spurious waves at the boundaries of the domain.
These two practices, however, are not always effective since an increase in accuracy may require larger stencils which may introduce spurious waves at the boundaries of the domain, while by increasing of the resolution of the grid one may increase the computational time.
