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Fourth, vitamin D deficiency increases bone remodeling and may increase serum osteocalcin levels.
Sorafenib may increase serum concentration of doxorubicin and irinotecan, and may decrease serum concentration of fluorouracil.
Concurrent use of digoxin and oral antibiotics such as tetracyclines may increase serum digoxin concentrations in some individuals.
This may increase serum levels of IL-6 and provide the basis for the amplification step of chronic inflammatory proliferation.
Supplementation may increase serum zinc, but the magnitude of the effect appears to differ across populations and interventions.
Furthermore, animal studies have confirmed that perturbation of the GCKR metabolic pathways may increase serum TG concentrations [ 21, 22].
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Physical conditions such as pregnancy, pelvic inflammatory disease, benign cysts, uterine fibroids, or infection may also increase serum CA-125 levels [7], [8].
Several other conditions, such as use of alcohol (78, 79), liver disease, and collagen diseases, may also increase serum ferritin concentrations.
The high bone turnover releases skeletal phosphate and calcium and may further increase serum phosphate levels (see above).
Fructose may also indirectly increase serum levels of uric acid by increasing insulin resistance, leading to impaired glucose tolerance, and elevated circulating insulin levels [ 18, 20, 21, 42, 43].
It was reported that in patients with advanced liver fibrosis, there was a decreased level of serum vitamin D. In such patients, active exposure to sunshine may increase the serum vitamin D level.
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