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In contrast, high dietary intakes of dairy products and meat may increase prostate cancer risk.
However, rising estradiol levels may increase prostate sensitivity to testosterone via upregulation of AR (32, 33).
Obesity and its hormonal and metabolic correlates may increase prostate cancer progression and decrease survival.
Dvl2 may increase prostate cancer growth and metastatic potential by up-regulating Wnt3a expression [ 86].
Certain metabolic alterations sustained in obese men, such as increased levels of insulin, insulin-like growth factor-1 (IGF-1), and leptin may increase prostate cancer risk.
In conclusion, the results from this large prospective study are consistent with the hypothesis that a high intake of protein or calcium from dairy products may increase prostate cancer risk.
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Sirolimus may also reduce kidney cancer risk but did not appear protective for other cancers, and it may actually increase prostate cancer risk.
Diabetes results in higher circulating insulin and glucose levels and perhaps higher free insulin-like growth factor I (Giovannucci, 2001), which may be growth enhancing and therefore increase prostate cancer risk.
We had hypothesized that the magnitudes of increases in estrogens following finasteride treatment may have increased prostate cancer risk.
Other biomarkers, such as urinary prostate cancer antigen 3 RNA, may increase accuracy of prostate cancer screening compared to PSA alone.
These various findings have led to the hypothesis that exposure to some organochlorine compounds may increase risk of prostate cancer.
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