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Pulse‐delivered inhaled nitric oxide may improve oxygenation but may increase plasma concentration of the potent vasoconstrictor, endothelin‐1 (endothelin‐1
The decrease in C1-INH activity may increase plasma concentration of bradykinin, the key mediator of HAE-C1-INH symptoms.
The mere in vivo presence of leukemia may increase plasma levels of stress hormones and PGE2.
Trauma, burns and major surgery are all conditions that may increase plasma viscosity.
More limited evidence suggests that exposure to Pb may increase plasma homocysteine concentration.
Itraconazole may increase plasma concentration of cyclosporine, certain benzodiazepines (midazolam, triazolam, alprazolam, and estazolam), digoxin, and cisapride.
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Furthermore, cyclosporine also exerts structural nephrotoxicity which may further increase plasma renin activity [18], [25], [34].
Grapefruit juice may also increase plasma concentration of sirolimus.
Pharmacological interventions, such as thiazolidinediones, ACE inhibitors, angiotensin II receptor blockers and fenofibrate, may all increase plasma adiponectin concentrations [ 4].
Because inflammation from opportunistic infections may also increase plasma HIV-1 RNA levels, it is possible that the association we detected between HIV-1 RNA and endothelial activation was due primarily to immune reconstitution and undiagnosed opportunistic infections in this population.
Therefore in a patient with the -174C allele and early/established nephropathy, the additive effects may be to increase plasma IL-6 and subsequent ROS generation.
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