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Protein overexpression, however, may increase nonspecific interactions.
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When Dot1 or Set1 is deleted, SIR complex may have increased nonspecific binding to euchromatin and thus decrease silencing at heterochromatin.
Any cell that is damaged may potentially have increased nonspecific binding.
This indicates that high dose treatment may result in increased nonspecific binding which eventually counteracts the tumour inhibitory effect of the fusion protein.
RNA sample mixture complexity may increase the amount of nonspecific hybridization, magnify GC skew and boost the intensity of MM oligos at all levels.
Although there has been some speculation that the development of preclinical IA could be increased by exposure to enteroviral or rotoviral infections, another theory, the hygiene hypothesis, is that reduced microbial exposure and nonspecific infections may increase the risk for type 1 diabetes (12, 13).
However, contaminants may increase cell permeability and hence inhibit substrate uptake by a nonspecific action.
The use of a more open membrane (plasmafilter) coupled with adsorption may increase the adsorptive capacity of the system and achieve higher nonspecific clearance of inflammatory mediators [ 43].
Nonspecific symptoms, the absence of routine rectal examination, and patient reluctance to undergo rectal exploration may increase delay [ 21, 22].
If anything, it may increase.
"De-stocking activities may increase.
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