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Use of disc-like nanoparticles may increase endothelial cell interactions and thus enhance their ability to extravasate into tumor tissues [30, 31].
However, whereas VSL#3 has been associated with reduced gut epithelial permeability and thus reduced antigen translocation induced inflammation, telmisartan may increase endothelial permeability (Bian et al. 2009).
Because activation of the PKC pathway may increase endothelial permeability [25] and because HBP is shown to stimulate PKC activity [26], we tested the hypothesis that HBP increases permeability via the PKC pathway.
Flavonoids may increase endothelial NO production [53], [54] by stimulating Akt-mediated endothelial-derived NO synthase activity [55], [56], and additionally decrease levels of the vasoconstrictor endothelin-1 [53].
Vitamin C may increase endothelial nitric oxide (NO) by protecting it from oxidation and increasing its synthesis [ 21, 22].
Acting together, these mechanisms may increase endothelial cell apoptosis, diminish production of endothelial-derived nitric oxide, and increase endothelial exposure of procoagulant tissue factor and phosphatidylserine.
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This high correlation between the three factors indicates a common pathway is involved in the formation various vitreoretinal disorders (Figure 3, 6); IL-6 is a multifunctional cytokine that may indirectly cause an increase of vascular permeability by inducing the expression of VEGF [30] or alternatively may directly increase endothelial cell permeability [31].
We would predict that the endothelial-derived microvesicles may increase upon endothelial cell damage.
Fenofibrate's hypotensive effect may reflect increased endothelial NO bioavailability and reduced endothelin-1 production.
The high levels of soluble CD146 found in RA synovial fluid, particularly in early disease, may reflect increased endothelial activity and angiogenesis.
BSNXD may enhance proliferation of estrogen-sensitive cells, and thereby increase endothelial reactivity to E2.
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