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Low-fat diet with high n-3 fatty acids may increase circulating IGF-I concentrations without adversely affecting insulin sensitivity in healthy individuals.
GC may increase circulating FFA by inhibiting lipoprotein lipase and thereby increase both the uptake and turnover of fatty acids in adipose tissue.
The stress from the surgical pathology, pain and anxiety may increase circulating catecholamine levels in patients requiring an emergency laparotomy.
Furthermore, increased adiposity may increase circulating levels of free fatty acids (FFA) and subsequently the quantity of FFA the liver is exposed to [ 11, 12].
Further, most pharmacokinetic studies have looked at single doses of resveratrol [ 70], yet resveratrol can be taken daily and this may increase circulating blood levels.
These results suggested that repeated IFR therapy did not promote EPC mobilization after tissue ischemia but may increase circulating EPCs' homing to ischemic tissue.
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Medium chain triacylglycerols (MCT) have been suggested as efficacious in weight management because they possess greater thermogenic qualities relative to long chain triacylglycerols; however, MCT may also increase circulating lipid concentrations, possibly increasing risk of cardiovascular disease (CVD).
A recent review also suggested that long-term exercise may actually increase circulating IGF1 (Nindl & Pierce 2010).
12 In addition, lifestyle choices mean that pregnant women in the developed world often consume high glycaemic snacks between meals that may temporarily increase circulating glucose and insulin concentrations.
However, not only may aromatase inhibitors increase circulating endogenous androgen concentrations, but some possess intrinsic androgenic activity by binding to and activating the AR [ 78, 87] – highlighting the limitations of pharmacological blockade of steroidal mechanisms, where blockers or their metabolites may have off-target effects.
Given that GLP-1 is a physiological substrate of DPP-4, DPP-4 inhibition by vildagliptin may be expected to increase circulating levels of GLP-1 (19).
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