Ultimately, these improved physicochemical properties of lipid-coated SPIONs may significantly increase biological circulation time after systemic administration allowing more effective delivery of therapeutic payload to desired target cells.
This suggests that grazing may increase the biological function of milk because it is thought that sialic acid is significant in many ways.
It has been speculated that the unusual amino acid bromotryptophan makes these AMPs less susceptible to proteolytic degradation and may increase the biological activity of the peptide (Li et al. 2010).
Untreated sexually transmitted diseases may increase the biological susceptibility [ 4, 5].
This may increase the biological demand for vit E in the feed, and thus modify the beneficial effects of silage [ 18].
It has been previously revealed that genistein esterification with various fatty acids may increase its biological activity both in vitro and in vivo, by raising its cellular uptake [ 20].
Although the catabolism of ATRA and 13cisRA potentially limits clinical use, agents that inhibit ATRA metabolism, such as acitretin or CYP26 inhibitors, may increase its biological availability and directly affect the efficacy of retinoid treatment.
Secondly, it has been postulated that higher estrogen concentrations may confer increased biological aggressiveness on hormone receptor-positive tumors, as BMI is directly related to circulating estrogen levels [ 22, 35, 36].
Disruptions in daily activities and social interactions could act as 'social zeitgebers' which may contribute to increased biological abnormalities (e.g., hormonal, metabolic).
There may also be increased biological activity in hepatocytes, as early studies provided evidence of in vitro and in vivo radical curative synergy between chloroquine and primaquine in P. vivax malaria (7, 38).
