Sentence examples for may increase binding from inspiring English sources

A secondary feature of the T7-bias domains is that they are GC-rich and distally located on the molecule which may increase binding affinity.

They include adjacent DNA elements and/or post-translational modifications of E2F protein, which may increase binding affinity, as well as chromatin modifications that would increase accessibility to the DNA and E2F interactions with other transcription factors, which allow the formation of more stable, cooperative multimeric complexes [8].

Our results highlight several characteristics that may increase binding potency to PPARγ.

HA-186V may increase binding affinity for the α (2– 6 -linked sialic acid receptor (10, 11 ).

Thus, our analysis suggests that both signals may increase binding affinity, and that 10 11 bp periodic sequences are ubiquitous enough in the genome to be readily utilized by the subset of stable nucleosomes.

In keeping with this model, we show that, in SW-1353 cells, rosiglitazone and LG268 result in similar levels of consensus DR-1-driven reporter activation, suggesting that treatment with each compound may increase binding to the DR-1 element.

While the V9I mutation in the DNA-binding domain is likely to increase the dox-induced binding affinity of rtTA for the tetO site, the F67S, F86Y, and G138D mutations positioned in the regulatory core domain may increase the binding affinity for dox or facilitate the structural transition to the DNA-binding form [ 24, 26].

Kalia et al. (1984) proposed that the presence of excess manganese in the brain may increase the binding affinity of brain proteins to lead or may induce expression of a lead-binding protein, resulting in more toxicity than expected based on effects of exposure to lead alone.

Methylation at CpG sites may increase the binding of planar carcinogen compounds at the intercalation step (Geacintov, 1986), although the precise mechanism by which cytosine methylation at CpG sites enhances carcinogen binding still needs to be determined.

It could be concluded that the substitution of Phe in the codon 101 position, which may increase the binding activity of IFNβ with its receptors and introduction of an additional N glycosylation site (Asn-X-Thr) in the position 27 of IFNβ protein may cause such an effect.

Thus, captopril may increase the binding of anti-HPA-1a and confuse the determination of the cause of acute thrombocytopenia.