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Future extensions of this innovation may include studies of novel seawater RO membrane materials, optimization of membrane cleaning, or using the device as an ex situ fouling detector at a full-scale seawater desalination plant.
On the other hand, a review carried out to assess the preliminary evidence in favour of a new '-omics' test in order to judge whether it would be sensible or appropriate to carry out a large scale prospective evaluation may include studies from earlier phases which use the case-control type design.
These applications may include studies in crop science, plant breeding, evolutionary biology or systematics (22, 23).
These may include studies of a drug's mechanism of action or further investigation of a specific toxicity observed in a clinical or non-clinical study.
This additional searching is useful as a way of helping to identify both further published studies and unpublished studies (which may include studies available in the 'grey' literature, i.e. in sources of literature other than indexed, peer-reviewed journals) Are the searches up-to-date?
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Such facilities may include study rooms with a supporting library and equipment to assist in the examination of collections.
Future research direction may include studying the effect of FTS with corticosteroids, or alternatively with Glatiramer acetate which demonstrated improvement of strength and mobility in the same mouse model [24].
Some useful covariates may include study-related variables such as study quality, patient-related variables such as age or severity of disease, treatment-related variables such as duration or delay in receipt of treatment, etc.
Plausible reasons for the marked lower probability estimates at 31.25 μg BID compared with the 62.5 μg OD regimen may include study design factors, namely imbalance in patient dose allocation due to the incomplete block study design, or possible clinical under-performance of the 31.25 μg BID formulation.
Future research might also employ translational approaches using functional brain imaging or may include study designs other than clinical trials (such as population-based studies using SEER [Surveillance, Epidemiology and End Results] data linked to Medicare claims, although such designs also have limitations [ 35]) or both.
This assessment may also include study of metabolism (DMPK).
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