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PSMC1 (MIM 602706) is an ATP-dependent protease [17] that may include protein ubiquitination in response to DNA damage [18].
We also will need to develop appropriate screens for new categories of targets, which may include protein interactions and subcellular distribution.
Such changes may include protein modification and redistribution, or changes in intra- or extracellular metabolite levels, and can be visualized only via proteomic or metabolomic approaches.
Typically, networks are generated using interactions derived from a plurality of different experimental types, which may include protein interactions identified in both individual small-scale studies and larger systematic genome-scale screens – such as those from yeast two-hybrid (Y2H) and affinity-purification experiments.
Similar(56)
These chemical signals may include proteins from invading bacteria, clotting system peptides, complement products, and cytokines that have been given off by macrophages located in the tissue near the infection site.
These negative regulators may include protein-coding genes, as well as microRNA genes that could negatively regulate gene expression [49].
These may include proteins, nucleic acids, carbohydrates or other large molecules that do not interact directly or specifically with protein molecules (or other macromolecules of interest).
Overlapping isoforms of lincRNA have been reported previously and may include protein-coding genes [ 17].
Many proteins do not act as monomers in the cell but as part of multimeric protein complexes that may include proteins encoded by one or several distinct genes.
Their content may include proteins (e.g., signaling molecules, receptors, integrins, and cytokines), bioactive lipids, nucleic acids (e.g., miRNA, mRNA, DNA), and organelles [ 81– 81].
Molecule(s) causing these interactions are elusive and may include proteins that mediate constitutive loops between Hoxd gene promoters and their regulatory elements.
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