Sentence examples for may include mutations from inspiring English sources
Mechanisms for increased tolerance may include mutations in apoptotic pathways (such as caspase or p53) or upregulation of NHE-1.
Wild-type GISTs are heterogeneous in genotype and may include mutations in HRAS, NRAS, BRAF, NF1 or the SDH complex (Table 1).
Therefore, under the condition of 25 amplification cycles, approximately 1.1% of the products would include mutations in the hU6 hairpin region and 2.2% of the products may include mutations in the CMV hairpin region.
Thus, IDH1 mutations may require other key genetic events in a specific context for full-blown tumorigenesis, which may include SETD2 mutations as suggested by our cohort.
Genetic factors which may lead to Bid overexpression may include direct mutations to the Bid gene, which result in enhanced half-life of Bid protein within cells.
Other possible causes for the depletion of signals may include genetic mutations, alternative promoters, and epigenetic silencing through methylation that leads to aberrant silencing of normal tumor-suppressor function in cancer cell lines [ 48].
At the level of individual genes, changes affecting gene function may have included mutations, insertions and/or deletions in protein-coding sequences, changes in cis- and trans-regulatory domains, and even wholesale gene duplications/deletions.
Additional contributors to this scale may include de novo mutations, environment factors and/or epigenetic [22] events, most occurring during ontogenic development [23].
In choosing DTC carrier screening, consumers should also be informed that the panel of tests may include tests for mutations that cause adult-onset disorders, such as hereditary breast and ovarian cancer.
These may include somatic gene mutations, epimutations, loss of heterozygosity at an MMR gene locus, or maybe even unidentified microRNA silencing of a MMR gene.
The putative mechanisms of the acquired resistance may include T790M secondary mutations, loss of PTEN and activations of c-Met axis.
