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Only a small minority of asynchronously growing ALT cells have large APBs, and most of these appear to be growth arrested/senescent (T. Yeager and R. Reddel, unpublished data); the causes of growth arrest in these cells may include mitotic accidents.
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These remain to be determined, but may include necrosis, mitotic catastrophe and autophagy, as well as premature senescence [ 61].
Some possibilities include mitotic arrest, mitotic cell death, or mitotic slippage.
Factors contributing to this selective vulnerability may include the post-mitotic nature of motor neurons, their large size, the high level of mitochondrial activity and their relatively low calcium buffering capacity.
The complementary approaches may include a combined inhibition with other cellular factors, such as mitotic kinases and motor proteins [11].
Examples of such lesions may include atypical Spitz naevi, deep penetrating naevi, possible naevoid melanomas, or cellular blue naevi, where because of increased mitotic activity or cytologic atypia, a diagnosis of invasive or tumorigenic melanoma cannot be ruled out.
Side effects may include heartburn.
That may include its architect.
These may include speedier privatisations.
These may include vagrant rarities.
Reasons may include: Fatigue.
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