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There is strong evidence of genetic determination of circulating ACE and there is also evidence that this genetic determination may include loci unlinked to the ACE gene on chromosome 17.
Furthermore, from this comparative epigenomic work we propose the 's-DMR hypothesis' whereby regions of significant epigenetic difference between humans and other primates that are highly conserved at the sequence level may include loci subject to, or indicative of, human-specific environmental influence, potentially in association with pathogenic conditions.
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It may include single-locus "magic traits" but also cases where there is tight physical genetic linkage of the mate choice genes and the genes that affect ecology, which effectively imitate a true "magic trait" [ 8].
Additionally, > 40,000 unannotated loci may include potentially novel K. brevis genes.
Other problems that may be potentially clarified in future by using species-specific loci may include Hardy-Weinberg disequilibrium and null alleles.
Such complex loci may include overlapping architecture, such as cis-antisense, intronic, bidirectional, as well as non-overlapping with genes located in their close vicinity.
These mutants may include alleles at dhurrinase loci, and future work will be required to determine if this is the case.
Given that expression of our fluorescent protein-tagged 53BP1 derivative is correlated with higher foci counts, which may include numerous spuriously detected loci, we found this tool to be unsuitable for quantitative live-cell imaging.
Therefore, the Smr gene locus may include a further extended region in its 3′ end.
As noted earlier, each Locus may include several highly similar transcript isoforms, whose sequence differences could reflect splice variants, homeologs and paralogs, and sequencing errors.
The target genes located at this locus may include the telomerase reverse transcriptase gene (TERT) because a TERT gain was more frequently detected in invasive LS−/TC+ UGCs than intramucosal and invasive LS+ UGCs (16/26 vs. 1/37, P < 0.0001).
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