Histologic clues may include lack of carcinoma in situ, lack of central elastosis, pattern of infiltration around normal breast structures, yet none of these are specific.
Except of traditionally considered limitations, other reasons may include lack of stratification of analyzed cases based on clinicopathologic parameters, inclusion of patients treated postoperatively by different treatments or neglecting complexity of interactions among tumour constituents.
Primitive culture, in the lexicon of early anthropologists, any of numerous societies characterized by features that may include lack of a written language, relative isolation, small population, relatively simple social institutions and technology, and a generally slow rate of sociocultural change.
Reasons may include lack of knowledge about available resources or a need for things outside of what nonprofits can provide, according Liz Hamel of the Kaiser Family Foundation.
Some reasons for delayed presentation in our area may include lack of awareness of ideal timing for STI prophylaxis, financial constraints, geographic barriers, and shame associated with disclosure of sexual violence.
Nosocomial infection is probably common, the reasons for which may include lack of hand wash basins and/or hand washing, overcrowding in hospital wards and clinics, lack of infection control training or policies, an inability to isolate specific patients, and a lack of awareness of the presence of nosocomial infection resulting from a lack of diagnostic microbiology facilities.
Additional challenges for rural communities may include poverty, lack of education, lack of access to condoms and unemployment.
Other factors that may inhibit metamorphosis include lack of food, lack of trace elements and competition from conspecifics.
These barriers may include a lack of knowledge, a lack of financial resources and a fear of side-effects among patients, as well as concerns of adherence and the risk of re-infection at the provider level [ 11].
Reasons for this may include a lack of awareness among clinicians, a lack of confidence to tackle a notoriously sensitive issue or an unwillingness to overburden families who face many challenges already, such as intense therapy schedules [ 3, 55] and socio-economic pressures [ 11].
While a national PBCR may be ideal, the challenges to establishing such registries may include the lack of a uniform reporting system, the lack of a single national identification system, the multiple levels of independent healthcare delivery and the poor distribution of expertise in cancer diagnosis and treatment.
