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The underlying mechanisms by which heparins inhibit tumour progression are incompletely understood, and may include inhibition of selectin-mediated cellular adhesion, inhibition of tumour invasion, and induction of cancer cell apoptosis (Smorenburg and Noorden, 2001; Niers et al, 2007; Lee, 2007).
Therefore, the protective effects of IKKα in response to DNA damage may include inhibition of IKKβ activity.
The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis.
Fungal interactions may include inhibition of growth of coexisting fungi, a potential defence system for mycoparasitic competitors such as ascomycete Trichoderma spp. that are known to parasitize a range of fungi [ 68].
The neurotoxicities observed with MS-275 and MLN518 are perhaps due to the broad inhibition profile of such type of inhibitors, which may include inhibition of the muscle-type nicotinic receptor.
Potential mechanisms for cytokine-induced reduction in GR function and affinity may include inhibition of GR translocation from cytoplasm to nucleus and reduction in GR-mediated gene transcription [ 68].
Similar(49)
This raises the question of whether blockade of ErbB2 oncogenic signaling by PEPD may also include inhibition of ErbB2 heterodimer signaling units.
Future research directions may also include inhibition of EndMT, preservation of endothelium-derived hyperpolarizing factors, pharmacological maintenance of eNOS activation in altered shear stress conditions, and silencing of endothelial proinflammatory genes.
These mechanisms may include feedback inhibition, forward feed, metabolite channelling, and counteractive metabolic and cellular perturbations.
Strategies for recovery may include functional inhibition of the intact hemisphere, rerouting of connections, or setpoint-mediated network plasticity.
The exact mechanisms by which expression is repressed are still under investigation but may include the inhibition of protein synthesis, the degradation of target mRNAs, and the translocation of target mRNAs into cytoplasmic processing bodies (Jackson and Standart 2007).
More suggestions(15)
may involve inhibition
may include avoidance
may overcome inhibition
may include heartburn
may be inhibition
may escape inhibition
may include firearm
may augment inhibition
may include coriander
may include Practicing
may include brain
may initiate inhibition
may mediate inhibition
may include starvation
may include clothing
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