Sentence examples for may include epigenetic from inspiring English sources

The mouse lymphoma L5178Y Tk+/− assay is broadly used in toxicology to assess genotoxicity because of its known sensitivity to genotoxicants that act through a variety of mechanisms, which may include epigenetic DNA methylation.

The underlying mechanisms may include epigenetic modulation of major inflammatory pathways, yet the details remain unclear.

The appearance of RNA fragments only in young flies after mating could be due to subsequent changes that may include epigenetic modifications, which increase the efficiency of the removal of such fragments during repeated matings.

The mechanism by which Acs2p activity affects age-associated autophagy may thus include epigenetic control of ATG gene transcription, as exemplified in this study by regulation of ATG7 mRNA and protein levels.

Possible mechanisms that may explain this increased cancer risk include epigenetic changes such as altered DNA methylation and changes in chromatin structure, which may cause imprinting disorders and modified gene expression [ 39].

Such filters may include data about epigenetic modifications or DNA accessibility, the observed binding of TFs, or sequence conservation (phylogenetic footprinting).

Despite much research effort, the aetiology is not fully understood, and may include genetic susceptibility, epigenetic regulation and environmental factors [ 2].

The potential mechanisms driving aberrant expression of Bcl-2 proteins in tumor cells are diverse and may include gene amplification, epigenetic changes, posttranslational modifications as well as overactivation of upstream transcription factors (e.g. NFκB. STAT3).

This indicates that other regulatory mechanisms of MAL silencing also exist in gastric cancer, which may include DNA copy number loss, other epigenetic mechanisms, altered expression of transcription factors regulating MAL or microRNAs targeting the MAL gene.

Other possible causes for the depletion of signals may include genetic mutations, alternative promoters, and epigenetic silencing through methylation that leads to aberrant silencing of normal tumor-suppressor function in cancer cell lines [ 48].

However, the average methylation levels were significantly higher in neoplasia-free subjects compared with cancer patients (Table 2) This observation suggests that epigenetic field changes may include both loss and gain of methylation.