Based on previous work, whereby high glucose reduces AMP levels, AK flux and AMPK activity [43], [69], [70], [71], possible mechanisms for the observed effect of hyperglycemia may include diminished adenylate kinase flux and related AMPK-PGC-1α signaling critical in mitochondrial biogenesis [57], [63].
Mechanisms remain obscure but may include diminished adherence to medical regimens, and self care including healthful diet and exercise.
Personal costs for clients and their caregivers may include diminished quality of life, incapacities and social participation restrictions and financial burden.
Ministers get on with ideology, which may include diminishing Whitehall and public services.
Symptoms of hypogonadism may be also include diminished sexual desire and erectile quality, particularly in nocturnal erections, as well as changes in mood with concomitant decreases in intellectual activity and spatial orientation, fatigue, depression, and anger.
Clinical presentation may include pallor, diminished or absent pulses, compartment syndrome or gangrene.
There may also be, very prominently, a large range of abnormal (and often "paradoxical") sensory responses, with some sensations being heightened and even intolerable, others (which may include pain perception) being diminished or apparently absent.
Pharmacological agents able to diminish EBI may include vasodilators (calcium blockers, magnesium sulphate, ET-1 antagonists, NO donors, milrinone, and oestrogen therapy), antioxidants, anti-inflammatory, or antiplatelet agents [ 13] and iron binding molecules.
Tumours of the endocrine pancreas are difficult to diagnose because findings are nonspecific and may include diabetes, gallstones, excessive fat in the stool, indigestion, and diminished secretion of gastric acid.
Potential reasons for low triptan refills may include the side effects of triptans, lack of efficacy, uncertain diagnosis of headache, and diminished headache frequency or headache improvement.
The mechanism of PONV is complex and may include the stimulation of the chemoreceptor trigger zone by residual anesthetic, vestibular nerve disability, diminished peristalsis, elevated digestive tract inner pressure, and psychological reasons.
