Although low-dose cytarabine is frequently used, the mechanism of action is not known in detail and may include differentiation induction, as well as direct cytotoxic effects [ 85].
The underlying mechanisms may include differentiation of the mammary epithelial cells, reduced number of mammary stem cells, altered mammary response to oestrogen, and reduced levels of circulating hormones (Britt et al, 2007).
This should include differentiation between urban areas generally and those in capital regions such as Nairobi, which may enjoy special advantages due to proximity to central government.
I offer suggestions and recommendations for embedded frameworks, which include differentiation strategies, appropriate to meeting student needs.
These results suggest that the interval between expansive growth and ripening may include further developmental differentiation; an emphasis on defense would be consistent with the role of fruit in protecting the developing seeds during embryo maturation prior to facilitating seed dispersal.
These observations suggest that molecular genetic changes accumulate in bone marrow MSCs during aging that may affect functions, including differentiation and proliferation of these cells.
In general, this response may include cell activation and differentiation [27], [28], secretion of type I IFNs, and/or production of proinflamatory cytokines [17], [29].
Under conditions of stress or injury, the pericyte undergoes phenotypic and functional changes that may include migration, proliferation or differentiation.
Many affected genes are known to be involved in sarcomagenesis; others are novel, including mediators of adipocyte differentiation, and may include valuable therapeutic targets.
For ILC, the differentiation features may include multifocality, difficulty of clinical detection, posterior acoustic shadow and isodensity or hypodensity [19].
Integration of such signals can result in alteration of the otherwise quiescent state of MSCs, eliciting a sequence of fate choices that may include proliferation, self-renewal, migration, differentiation and cell death.
