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The response involves recruitment and activation of macrophages and may include activation of a mild foreign body response with the formation of multinuclear giant cells, depending on the material format and location of implantation.
The mechanism of presynaptic facilitation, therefore, may include activation of one or more serotonergic neurons, which enhance the release of a neurotransmitter by increasing the intracellular concentration of cyclic AMP in the terminals of the sensory neurons.
38 Other putative mechanisms may include activation of matrix metalloproteinase-9 followed by dysfunction of the neurovascular unit.
Downstream effects of cGMP may include activation of a number of effectors, such as ion channels, protein kinases, and phosphodiesterases [ 29].
The mechanisms leading to tumor promotion may include activation of the neutrophils' inflammatory potential such as the release of MPO and serine proteases from neutrophil granule contents [ 14– 16].
Such non-monotonic dose response curves are well known for many normal physiologic mechanisms that may include activation of different pathways at different dose levels and down-regulation of receptors at high hormone or EDC concentrations.
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Our findings suggest that gene activation by RA may include active or passive DNA demethylation of CpG and potentially also of non-CpG sites in gene promoters.
In general, this response may include cell activation and differentiation [27], [28], secretion of type I IFNs, and/or production of proinflamatory cytokines [17], [29].
The mechanisms involved in Nox4-dependent antiapoptotic effects may include the activation of kinases such as Akt [257] and Jak-2 [259].
Most apoptosis is accompanied by a complex cascade of intracellular events that may include the activation of pro-apoptotic Bcl-2 family members, caspases, and several nucleases.
The response of cells to oxidative stress may include the activation of genes with the antioxidant responsive element (ARE) via the transcription factor Nrf2 (NF-E2-related factor 2) (Lee et al. 2003a).
More suggestions(15)
may induce activation
may include heartburn
may foster activation
may attenuate activation
may facilitate activation
may include firearm
may enable activation
may cause activation
may include coriander
may trigger activation
may include brain
may include Practicing
may include starvation
may enhance activation
may have activation
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