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The molecular genetic components contributing to idiopathic CHD may include accumulation of multiple rare genomic and epigenetic variants converging to dysregulate cardiac developmental genes leading to mutational loading of developmental networks [ 3].
Shared induction mechanisms among Hsp20 proteins may include accumulation of denatured proteins in the cytoplasm [ 2], generation of reactive oxygen species [ 40], or changes in membrane lipid composition and fluidity [ 57].
Although complete gene loss can be regarded as a final step in evolution, prior steps may include accumulation of point mutations eventually leading to pseudogenization, and an increase in the ratio of nonsynonymous (d N) to synonymous (d S) substitutions, ω, is often used to demonstrate relaxed selection of genes (e.g., Krause 2011; Barrett et al. 2014; Wicke et al. 2014).
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The feedback may include the accumulation of knowledge about your drugs potential side effects.
The biological responses to these pollutants include accumulation and degradation.
The mechanisms of cisplatin drug resistance may include decreased intracellular accumulation of cisplatin and increased DNA repair, which also are drug resistance related pathways considered in this approach.
Evidence suggests that the mechanisms responsible for platinum resistance in ovarian cancer may include reduced drug accumulation, increased levels of glutathione and metallothionein, and enhanced DNA repair [3]– [5].
For instance, puddles can refer to a range of habitats which may include roadside water accumulations, tire tracks, hoof/foot-prints, rain and groundwater pools, and rock-pools.
However, other factors may be involved, including accumulation of lactate, pyruvate, glutamine and free glucose, and depletion of glycogen, ketone bodies and glutamate.
The possible mechanism for this lipid accumulation may include: carbon tetrachloride-induced decrease in the secretion of lipids from the liver [28] as well as increase in the synthesis of lipids in the liver [29].
The definition of lipoatrophy was based on the development of peripheral fat wasting (face, arms, buttocks or thighs) and/or central abdominal fat accumulation, and may include enlarged breasts.
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