Sentence examples for may inactivate the from inspiring English sources

Finally, group C consists of the receptors Smed-egfr-5 and Smed-egfr-6, the latter with key amino acid substitutions that may inactivate the ATP binding and active sites of the tyrosine kinase domain (Supplementary Figure 2).

Mutations in residues 271 and 274 of RT may inactivate the virus, which may enter cells but can not replicate.

It is recognized that occasional mutation types overlap, e.g., a silent mutation may activate a cryptic splice site or may inactivate the normal splice site if it disrupts the splice donor consensus sequence [30].

It is likely that in the SynCre Gabrb3flox mice the Cre may inactivate the conditional Gabrb3 allele too late in development to interfere with palate elevation and fusion which occur during E13.5-E14.5.

Together these data suggest that iAs may inactivate the enzymatic activity of either CBP, p300 or both proteins because although they are associated with the promoter, one of their targets, H3K18 is not acetylated when iAs is present.

In support of a general blockade of UPS-dependent protein degradation, it has been shown that the presence of a mutant polyglutamine tract can hinder a protein's proteasomal degradation [14], [15], leaving open the possibility that long polyglutamine stretches may inactivate the 26S proteasome by becoming trapped in the proteolytic chamber [16].

However, bacterial factors such as streptococcal pyrogenic exotoxin B (SpeB) may inactivate these peptides.

This further suggests that siramesine may inactivate even the structurally similar F-type ATPase in the mitochondrial membrane, thereby contributing to the loss of mitochondria energy production.

41, 59, 60 Extremely high temperatures and prolonged periods without rainfall in the Arabian Peninsula may inactivate oocysts in the environment rapidly, thereby reducing transmission to humans directly by soil contact or indirectly by food animals such as sheep and goats.

As statins suppress the production of metabolic products, including geranylgeranyl pyrophosphate (GGPP), from mevalonic acid to cholesterol synthesis, they may inactivate Rho through the suppression of GGPP synthesis and down-regulate PAI-1 mRNA expression.

Though not experimentally validated, two of these mutations, including the splice site mutation and the R353C mutation, were predicted as potentially damaging mutations that may inactivate NOTCH1 activity based on the analysis of their potential structural effects [ 48].