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Angiotensin II improves in vivo gene expression by adenovirus upon intra-arterial delivery and thus may improve gene therapy efficacy.
The findings suggest that intra-arterial delivery of angiotensin II with adenovirus augments expression and thus may improve gene therapy efficacy and that SSTR2-based reporter imaging is useful in comparing methods for enhancing gene expression in vivo.
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Automation of HER2 FISH may improve HER2 gene testing.
Similarly, the discovery of 173 FLcDNAs that do not have corresponding gene predictions in the current genome annotation may provide an opportunity to further improve gene prediction tools for poplar.
The authors used multiple sgRNAs targeting the same gene to improve gene disruption efficiency, which may potentially increase the off-target effects.
Stem cells could also improve gene therapy.
While reliability of FFPE methodologies may be improving, carefully processed fresh biopsies may improve reliability of gene expression arrays and of some immunohistochemistry assessments.
The ability to distinguish between muscle-derived transcripts and genes over-expressed due to leukocyte infiltration may improve the interpretation of gene expression results and increase existing knowledge of molecular pathways critical for myositis.
For instance, we have assumed, for simplicity, that each solvent-associated gene is activated at the same threshold pH value; assigning distinct threshold values to each gene may improve the accuracy of the model.
Thus, the ability to assay whole blood without sample fractionation or globin reduction may result in improved gene expression profile quality and decrease cost.
The use of β-2-microglobulin, RPL32 and RPL17 as internal standards may improve the accuracy of gene expression studies aimed at muscle tissue engineering under the proposed settings.
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