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The innovative gas diffusion method system may improve gas retention time, thus a higher gas liquid mass transfer and ethanol concentration.
While early observational studies suggested that neuromuscular blockade may increase rates of ICU polyneuropathy, a recent RCT suggested that neuromuscular blockade, itself, may improve gas exchange and biological markers of lung injury.
The presence of spontaneous breathing (SB) activity may improve gas exchange during mechanical ventilation.
The application of periodic deep insufflation (sighs) during invasive mechanical ventilation may improve gas exchange [ 33- 35].
In adults with ARDS, HFOV can be safely applied and may improve gas exchange compared with CMV [ 8].
By increasing the lung volume, alveolar recruitment may render ventilation more homogeneous, may improve gas exchange and may limit distention of healthy lung units.
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In patients with severe hypoxemia or high cardiac output, where ECMO may not improve gas exchange sufficiently to decrease aggressiveness of mechanical ventilation, continued invasive ventilation with high volume and FiO2 may bring about a vicious cycle with ventilator-induced lung injury [ 4].
Maintenance of spontaneous breathing activity during ventilatory support in acute lung injury (ALI) may improve pulmonary gas exchange, systemic blood flow, and oxygen supply to the tissues [ 1].
Experimental and small clinical trials suggest that biologically variable or noisy MV may improve pulmonary gas exchange, compliance and dead space by preventing de-recruitment when compared to conventional MV [ 2, 3].
In addition, NAVA allows a more natural breathing pattern characterized by greater variability, which may also contribute to improve gas exchange [ 67] (see below).
Alveolar recruitment maneuver (ARM) using high airway pressures has been shown to re-expand atelectasis and to improve gas exchanges after general anesthesia; however, ARM may lead to lung stretching-induced inflammatory response.
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