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Although the effects of relaxin on loss of matrix macromolecules, particularly collagen, have been demonstrated in the fibrocartilaginous pubic symphysis [ 4- 7], this is the first study to demonstrate a similar targeting of fibrocartilaginous tissues from the synovial TMJ, and may implicate this hormone in the pathogenesis of TMJ disease in a subset of women with these disorders.
The observation that plasma proteins present in the OA joint can stimulate macrophages provides important rationale for further study of this pathway in OA models, but also may implicate this pathway in a variety of other local joint conditions that may produce alterations in synovial diffusion properties.
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Since the deficiency (dATRX1) had a similar effect in this assay to the dATRX3 mutation, this may implicate the long isoform in the heterochromatic function of this protein.
This may implicate the dual role of AP-1 in increased cell proliferation and cell death [ 48].
This may implicate that inflammatory pathways might not be correlated with knee OA; moreover, Onat et al. reported that there is discordance between insulin resistance and MetS [ 39].
A polybasic region is a class III consensus motif for binding to a SH3 domain [ 91]; therefore, this may implicate the polybasic region as a prototype of the AIR.
In addition, the dominant expression of PIF1 or SKI2 members in males is interesting, because three of three and three of six genes in the PIF1 and SKI2 subfamilies, respectively, appeared in the 'male dominant groups' (Supplementary Table S5C), and this may implicate these genes in male-specific functions such as spermatogenesis.
(32) Thus, this link may implicate the role of IRF-1 and interferons in these settings as well.
Given that only the genomic regions flanking the immobile mPing copies were analyzed by the TMD method, this observation may implicate that one factor for ensuring stability of the immobile mPing copies is due to the rapid CHG hypermethylation which might have been capable of compensating for the almost inevitable loss of CG methylation during callus culture.
Future studies may implicate the need to include gender in this list.
"The issue may implicate the First Amendment rights of many New Yorkers, and thus concerns important public policy of the state," the court wrote.
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