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If so, the canonic control of its promoter by DNA methylation may implicate epigenetic mechanisms in neuroprogenitor fate and function in the CNS.
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Recent findings further implicate epigenetic modifications in the control of allelic choice in the immune system.
Collectively, these results implicate epigenetic silencing of the BRCA1 gene in sporadic breast tumorigenesis.
The findings implicate epigenetic control of gene expression in addition to transcription factor networks.
Our findings indicate that control of BDNF expression may implicate the interplay of two epigenetic pathways, where SIRT1-mediated deacetylation appears to influence MeCP2 binding to methylated DNA.
Candidate genes in these two causal regions may implicate aberrant glutamate signalling interacting with epigenetic factors in some ASD cases.
This influence of chronic pain complaints on gene expression possibly implicates epigenetic modification.
Recent studies have implicated epigenetic mechanisms in the development of endocrine-resistant breast cancer.
An additional possibility may entail epigenetic modifications.
The effects of diet are potentially complex, and more studies are also needed to examine the effects of related dietary nutrients, such as vitamins B2, B6, B12, methionine and choline, which may also be implicated in epigenetic effects through the effects on folate-mediated one-carbon metabolism.
If correct, the canonic epigenetic methylation of the Ecrg4 gene that characterizes augurin production [ 17] may forecast the progenitor response to injury, and may therefore implicate the CP in defining the regenerative capacity of the CNS.
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