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Higher regional methylation of this enhancer, caused through increased methylatable CpG sites, on the susceptibility haplotype may impede its action in terms of enhancer-specific transcription factor recruitment, subsequent chromatin DNA looping, enhancer-promoter interaction and enhanceosome formation [51] with subsequent down-regulation on IRX3 expression.
However, significant limitations and challenges may impede its use.
Economics and stability of the material may impede its widespread application, though.
Another limitation is that the subcellular location of a protein may impede its destruction by the cellular protein degradation machinery.
Although RAD001 has a substantial impact on the HER2-overexpressing cell lines, the enhanced HER3 signaling may impede its long-term efficacy.
Discordant views on task shifting of HIV care duties may impede its successful implementation and undermine attempts to formulate policy, as has been documented in malaria vector management in Mozambique [ 17].
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Wound dressings are designed to support the wound bed and protect it from the factors that may delay or impede its healing such as contaminations and moisture-loss, thereby facilitating and accelerating the healing process.
If existentialism's very notoriety as a cultural movement may have impeded its serious philosophical reception, then, it may be that what we have most to learn from existentialism still lies before us.
Yet, Internet sovereignty is only one aspect of China's cybersecurity strategy, and its realization may impede or contradict with other priorities, such as economic growth or expanding Internet access to citizens.
In vitro and animal studies suggest that vitamin D and its metabolites may impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation typically characterized by G0/G1 cell cycle arrest, apoptosis, and suppression of invassion, angiogenesis, and metastasis [3] [6].
This, in turn, suggests that TbSTT3B requires the c-branch of the LLO oligosaccharide for efficient LLO recognition and/or transfer, whereas TbSTT3A does not; indeed, its presence may impede LLO recognition and/or transfer by TbSTT3A.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com