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A significant concern in the application of GE tools is the occurrence of 'off-target' activity and induced mutations, which may impede functional analysis and gene activity studies.
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It is sometimes necessary to remove affinity tags because they may impede functions of target proteins.
While the theoretical and observed functional redundancy may impede the analyses of their physiological roles, it also provides a safety net if DUSPs are to be targeted by pharmacological reagents in clinical trials.
ChIP-seq of histone modifications that mark active promoters and enhancers are informative, but their typical broader peaks may impede precise screening and identification of candidate functional variants.
Furthermore, three amino acid substitutions in the functional domains of Hsf1p may impede its interaction with the promoters of heat shock proteins; however, this supposition needs further experimental verification.
Additionally, a trade-off between reproduction and feeding was reported in cardinalfishes [ 10] and cichlids [ 11], suggesting that the functional coupling of feeding and brooding may impede morphological diversification [ 12].
Age is associated with greater functional decline and more cancer treatment complications that may impede the ability to benefit from higher-dose exercise compared with standard doses (Courneya et al, 2004).
In plants, variations in flower structure may impede pollination.
The reduction of these resources, say some, may impede research.
Democrats may feel reassured, because ineptitude may impede some of Trump's worst initiatives.
In essence the electrode may impede substrate access to the active site of the enzyme.
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