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Taken together, our results suggest that DNA variants in the upstream region of the ESR1 gene may impart risk to developing schizophrenia and that the mechanism of this risk may involve altered transcriptional control of cortical ESR1 mRNA.
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Although some genes not related to inflammation found in whole-genome panels may impart some risk to inflammation-associated diseases, associated genetic variants would be anticipated to be concentrated in a panel of SNPs in inflammation-associated genes.
Secondly, hormonal differences may impart differential risk of lung cancer between men and women.
However, an episode (or episodes) of GDM also may impart increased risk for disease beyond mere blood glucose abnormalities.
Fasting and 2-h glucose concentration may impart different risk for diabetes in men and in women, in that progression to diabetes appeared more dependent on fasting glucose in men and more dependent on 2-h glucose in women.
15 18 Of additional concern is the potential adverse effects of early or continued exposure to medical treatments (eg, second generation antipsychotics, some antidepressants) that may impart increased risk of obesity, glucose intolerance or a broader metabolic syndrome.
However, long-term safety remains incompletely understood, and some agents may impart undesirable risks for adverse outcomes, such as the potential for cardiovascular risk with rosiglitazone (37) or pancreatitis with exenatide (38).
This may impart particular risks for those in pre-pubescent or pre-parity windows of vulnerability [ 51].
These results may indicate that the pathways by which DEHP is metabolized may impart variable risks for altered thyroid hormones, based on the proportion of DEHP that undergoes oxidative metabolism compared with the proportion that is excreted as the monoester.
A reduced risk of colorectal and breast cancer was observed in Israeli OST recipients, 20 and there is some evidence that opioid use may impart a decreased risk of certain cancers.
Based on clinical experience, we hypothesised that female gender, older age, white race and total number of GDD in the operative eye may impart an increased risk of GDD exposure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com