Hence, when using DC to prime T cells for antitumour immunity, irradiation of DC may impair, though not eradicate, CTL generation.
However, innate immunity may be impaired not only due to the lack of direct antimicrobial activity but because of limited immunomodulating effects of defensins.
"The very high rates of depression among the youngest smokers, those aged 12-17, is very concerning, as it may impair their ability not only to stop smoking, but also to navigate the important developmental tasks of adolescence that are important for a successful adult life" said Mailman School of Public Health's Dr. Deborah Hasin, a senior member of the research team.
Unlike a healthy heart with isolated conduction disturbances, in which suboptimal efficiency may impair its function but not lead to impairment of physical capacity or survival, the dilated failing heart may be operating on a knife-edge in which even apparently minor inefficiency is compounded by adverse feedback processes in a way that impairs capacity and worsens survival.
"And it is a problem for the people whose liberties may now be impaired not by an independent decisionmaker seeking to declare the law's meaning as fairly as possible — the decisionmaker promised to them by law — but by an avowedly politicized administrative agent seeking to pursue whatever policy whim may rule the day".
These aspects may impair the diagnostic accuracy not only of GD but also of PCOS itself.
Thus, the hypothesis put forward by Jones and Bellomo [ 19], that dopamine may impair renal oxygenation is not supported by the data from Redfors et al. [ 23].
Maternal glucose intolerance may impair fetal insulin sensitivity (but not β-cell function) and consequently "program" the susceptibility to type 2 diabetes.
For many organizations, Information Technology (IT) enabled business initiatives and IT infrastructure constitute major investments that, if not managed properly, may impair rather than enhance the organization's competitive position.
