Sentence examples for may impair expression from inspiring English sources
In addition, demethylation may impair expression of efflux transporters, thereby leading to an enhanced efflux and chemoresistance (reviewed in [ 43]).
47, 48 SNPs in the intergenic region of 11p13 may impair expression of EHF and APIP, but also that of other proximate genes such as ELF5 and PDHX, so studies are ongoing to elucidate the mechanism of disease pathogenesis resulting from genomic polymorphisms.
The present study was designed to determine whether OSM may also impair expression of sinusoidal and canalicular drug transporters, which constitute important determinants of drug hepatic clearance.
On the basis of these in vitro findings, we investigated whether ablation of DHRS7 expression may impair the expression of genes involved in proliferation, migration, and adhesion.
A recent study also suggested that mitochondrial respiration deficiency may impair p53 expression and function (35), which is consistent with our observation.
Because prednisone may impair the expression of IFIGs by peripheral blood cells[ 5], medication used by patients at the time of blood donation could interfere with current results.
We focused attention on these islands as we would expect them to be unmethylated in young subjects yet contain many potential sites for age-related increases in methylation that may impair gene expression.
These previous publications altogether suggest that various processes may cause impaired expression of transgenes.
Because NeuroD1 is important for activating insulin mRNA expression, the decline in Wnt/β-catenin signalling in diabetes may impair de novo insulin mRNA expression by attenuating NeuroD1 expression.
Fan LH et al. [ 22] proved that HF diet may impair the function and expression of KATP channels in vascular smooth muscle cells by patch clamp and western blotting, which provides powerful evidence for our results.
While the current study shows definitively that miR-1 is not required for initial cardiomyocyte differentiation in vivo, the loss of miR-1 expression may impair further cardiomyocyte differentiation and/or maturation.
