These results indicate the necessity of preventing exposure to drugs that may impair sexual differentiation, which can compromise later mating success as well as the capacity to generate descendants.
Boddington et al. reported [ 21] that the iron oxide nanoparticle ferucarbotran may impair MSC differentiation, which hinders their potential use as fluorescence tracers for stem cells.
Overall, DISC1 dysfunction may cause impaired differentiation of oligodendrocytes by affecting Sox10 and/or Nkx2.2 expression and consequently contribute to the pathophysiology of psychiatric disorders.
Therefore, B52 depletion does not impair differentiation of this lineage, but delays its development.
While the current study shows definitively that miR-1 is not required for initial cardiomyocyte differentiation in vivo, the loss of miR-1 expression may impair further cardiomyocyte differentiation and/or maturation.
MSC aging may impair the survival, differentiation, and ability to recruit EPCs to areas of damage, ultimately reducing their therapeutic efficacy (Asumda, 2013).
2 Perturbations in T-cell function mentioned earlier may impair the maturation and differentiation of B cells into antibody-producing cells and memory cells; however, intrinsic defects in B cells are also notable in patients with WAS.
Diabetes may impair the process of recruitment and differentiation of adult pluripotent cells to sites of injury (1– 4).
The unusually low fractions of HIV-specific CD8+ Tdt and Tcm detected in progressive infection suggest impaired differentiation may be a key factor in HIV-specific CD8+ T cell dysfunction and progression to acquired immune deficiency syndrome (AIDS) [ 9, 10, 14].
The altered expression of hBDs by transformed keratinocytes may impair host immune recognition and control of cellular proliferation and/or differentiation [ 20, 21].
