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However, the cumulative effect of slight transcriptional modifications across the genome may impact overall cellular function.
Our results are similar in that the drink has its greatest impact in reducing GITI; however, this may impact overall health, but not activity levels of young children.
Specific antidepressants, for example trazodone, that have a high sedative potential and potential for DDIs with DAAs can lead to increased sedation and may impact overall tolerability and compliance to both agents.
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It is likely that the T cell maturation defect arises from the cumulative effects of relatively small gene expression changes within the Zfp335 regulatory network, possibly resulting in mild perturbations of multiple pathways whose functional consequences may not be individually significant but in combination may negatively impact overall T cell fitness.
This finding suggests that number of daily injections may not impact overall treatment satisfaction.
Students acknowledged that individual preferences and definitions of 'good' teaching may considerably impact overall course ratings.
More recent studies continue to suggest that salivary sparing is possible with IMRT using proper technique (Astreinidou et al, 2004) and may favourably impact overall quality of life (Reddy et al, 2001; Parliament et al, 2004).
Although manifested through potential increases in liver weight, the negative impact of nitrotoluenes on lipid metabolism has the potential for systemic impacts on energy metabolism that may negatively impact overall individual health and performance of physical activity as described by Wilbanks et al. [ 15].
Some investigators have found that follow-up intervals of up to 3 months may not impact overall survival from breast or colorectal cancer, whereas others have shown that women who waited more than 30 days for evaluation after the detection of breast cancer were more likely to experience cancer recurrence or death [ 4, 14, 19].
Energy saving is enhanced at the expense of reduced sensitivity which may impact the overall system operating range.
PROs augment clinical outcomes, providing a more comprehensive assessment of the patient experience, including symptoms and quality of life, that may impact the overall evaluation of new therapies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com