Sentence examples for may impact further from inspiring English sources

Consequently, it was decided to profile the compounds further for potential inhibition of human kinases and to study their DMPK properties to ensure that there were no major issues which may impact further development.

Moreover, C1INH deficiency is associated with pleiotrophic effects that may impact further upon morbidity, including an enhanced production of autoantibodies, thought to result from increased activation of B cells, which may provide the biological explanation for the reported association of the condition with systemic lupus erythematosus (SLE) 14– 14.

In these landscapes, the demand for locally collected seed often exceeds supply, and seed harvesting to meet growing restoration targets may impact further on remnant vegetation viability by reducing seed availability for natural population turnover, or reducing plant vigour through collateral collection damage (Lamont et al. 2001; Peres et al. 2003).

Once phosphorylated, TAU may impact intracellular signalling further implying a positive feedback mechanism such as that proposed for TAU-potentiated NGF-Erk1/2 activation [ 80] and/or by recruitment of Fyn to NMDA receptors [ 75].

Consequently, carious cavities remain untreated, which may lead to pain, discomfort and functional limitation and, further, may impact negatively upon general health and cognitive development.

Third, this study did not include other relevant conditions related to malnutrition, such as maternal education, variables on losses, food insecurity and coping mechanisms which may impact this association and further explain the mechanisms which lead to malnutrition after floods.

Further, in natural conditions other ecological factors not considered here such as interspecific competition, such as between Ae. aegypti and Ae. albopictus[ 34, 137], and predation [ 117] may impact development rate and warrant further investigation.

Based on the central role of serotonin in the pathophysiology of CH and these previous findings, it is plausible to hypothesize that further genetic variants may impact pharmacological effects involving the serotonin system and thus triptan response.

These same difficulties may impact contraceptive use in vaccine trials further limiting the number of female participants in these trials.

28 This is particularly notable because increased BMI is an established risk factor for cardiovascular disease, 29 may impact response to treatment, and could further burden patients with anxiety, depression and sleep impairment.

Lpxl1 NOMV are actively being considered as vaccines against meningococcal disease (van der Ley and van den Dobbelsteen, 2011), we therefore wanted to understand how a further lgtB modification may impact on human in vitro DC and T-cell responses.