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In addition to the specific sequence of operations required to deliver the necessary chemical and physical transformations for continuous drug substance manufacture, consideration is also given to how adoption of continuous technologies may impact different manufacturing stages in development from discovery, process development, through scale-up and into full scale production.
The CCIS introduction has included some types of bedside telemetry (patient monitors of vital signs) but not others (ventilators, for example), which may impact different HCP roles uniquely.
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"This transaction presents a classic case study in the inherent conflicts involved when tracking stocks are created and how a board decision may disparately impact different series of shareholders," said Desmonde Printz, a senior analyst at Proxy Monitor.
Modelling of heat exposure and the related effects based on existing physiological models is providing first stage estimates of how the increasing human heat exposure may impact on different population groups in different parts of the world.
Landscape networks and ecosystems worldwide are undergoing changes that may impact in different ways relevant ecological processes such as gene flow, pollination, or wildlife dispersal.
Epidemiological evidence from the Dutch Hunger Winter Famine suggests that specific periods of gestation may impact upon different organ systems in adult life to induce a metabolic phenotype that leads to obesity [23].
Additional costs incurred by CDMR may impact on different groups of patients.
Such heterogeneity in affected brain regions may, for instance, reflect the differential influence of environmental and genetic risk factors for obsessive compulsive disorder that may impact on different parts of the brain.
Social events may impact neighborhoods of different characteristics and the purchase behavior of people from different demographic groups in different ways.
18 20 Despite the correlation between different dimensions of socioeconomic circumstances, their components may impact fertility by different mechanisms.
These latter findings may confirm the assumptions that even the residual amount of the normal JAK2 allele may impact on the different Ph-negative MPN entities [ 21].
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