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Given that variations in illness severity may impact cognitive findings, there is a possibility that this was a contributing factor to the large differences between the overall study findings in this review.
Despite being one of the first genetic diseases identified, only recently, thanks to the phenotypic analysis of DS mouse genetic models, we have begun to understand how trisomy may impact cognitive function.
GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus.
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Some studies have shown that even subclinical levels of anxiety may negatively impact cognitive ability [16, 17].
For the past two decades, researchers have shown that elevated levels of circulating stress hormones may negatively impact cognitive performance in older adults.
Nevertheless whether a possible role of fat tissue per se and/or body composition may directly impact cognitive performance in older diabetics is lacking.
"One of my concerns is, if you have high blood pressure and you're 10 to 18 years old, it may impact your cognitive function more than if you're 40 or 50," he said.
Use of anesthetic drugs that decrease acetylcholine release (e.g., isoflurane) may impact on cognitive function after surgery [38].
Abnormalities in cognition have been reported in patients with Bipolar Disorder (BD) and their first degree relatives, suggesting that susceptibility genes for BD may impact on cognitive processes.
Further exploration of other factors that may impact upon cognitive function would be a useful addition to such tables as would information relating to change in profile of risk factors with increasing age, such as cholesterol level, risk behaviours such as smoking etc.
Use of anesthetic drugs that decrease acetylcholine release (e.g., isoflurane) may impact on cognitive function after surgery [ 38].
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