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Prognostic molecular biomarkers may identify pathways that can be exploited for therapy.
Overall, the identification and characterization of causative genes may identify pathways that are important for normal neuromotor function and help identify new targets for drug screens.
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Understanding the mechanisms involved through which CLA mediates regression may help identify pathways that limit or reverse human atherosclerosis.
Differences in gene regulation between Type II EMT and Type III EMT may help identify pathways that are specifically involved in fibrosis (Type II EMT) vs invasion and metastases (Type III EMT).
Molecular profiling may identify key pathways involved in tissue regeneration, drug metabolism and cell death [ 49, 50]; in studying copy number variants, we have shown that toxicities associated with docetaxel-containing chemotherapy regimens may be predicted [ 51].
The strategy of analysis of coordinated gene expression may help to identify pathways that act in concert to promote the complex process of melanoma development and metastasis.
By intersecting results of genetic correlation and positional candidacy, we may identify those pathways which are repeatedly associated with neurobehavioral trait variation, and thus perhaps the pathways that underwent selection in the generation of common laboratory strains.
The methods presented here may be useful to identify pathways and networks whose involvement in disease susceptibility are consistent with current models of pathogenesis, but most importantly may also identify statistically over-represented but unexpected pathways revealing novel disease mechanisms.
We suggest that a biological pathway-based approach is likely to be valuable in elucidating the genomic mechanisms underlying common diseases and may identify new pathways as therapeutic targets.
At the network level, differentially expressed genes may identify biological pathways that are perturbed in CAD.
Insights into these changes may identify important pathways, which can be activated using noncytotoxic therapies.
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