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The small proportion of cells required to achieve a paracrine effect may hinder detection of this mutation, when present.
Consequently there is likely a loss of phenotypic and genetic variation compared to individuals in the wild [ 1, 39, 40] including zebrafish [ 41], which may hinder detection of naturally occurring genetic mechanisms.
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Moreover, an interaction between genetic and environmental factors may hinder the detection of genetic effects if not accounted for, e.g., in genomewide association studies, and prospective cohort studies have hence been proposed to surpass the classic case control design.
This study evaluated patients only in the supine position, which may hinder the detection of posterior consolidation.
Data on test strips are less vulnerable to response biases that may hinder the detection of important relationships.
These abundant proteins may hinder the detection of low-abundant proteins that can be of specific interest in the search for biomarkers of disease [ 8].
The small size of both uORF and ncORF peptides may hinder their detection by mass spectrometry, as in the case of peptides translated by the Drosophila genes tal and scl (unpublished observation), and so absence of proteomic detection (or absence of functional data, see below) should not be used to disprove their translation.
The short length of the branch to the modern polar bear (supplementary fig. S1, Supplementary Material online) may hinder accurate detection of positive selection because short branches contain little information, subsequently leading to low power (Zhang et al. 2005; Nozawa et al. 2009; Gharib and Robinson-Rechavi 2013).
The portion of differentiated cells was always very small (approximately 20-25%) and at any specific time point only few cells may have been in the process of dying, which may have hindered detection of a "DNA ladder" on the gel.
The smaller sample volumes reduce the number of analytes detected and hinder detection [ 8].
The small sample sizes for parental accessions in this study may have hindered detection of transgressive transcription in F1 hybrids, through increased uncertainty regarding actual parental transcript levels.
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