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These data suggest that direct binding between the DNA glycosylase NEIL1 and the DNA damage sensor protein PARP-1 may help coordinate the repair of DNA damage.
A study [ 27] of efferent projections from the deep layers of the tectal neuropil to the hindbrain suggests that spatially patterned tectal outputs may help coordinate motor responses.
It has been shown that XPO5 (Exportin-5) is key to miRNA biogenesis and may help coordinate nuclear and cytoplasmic processing steps [ 35].
These results suggest that the interaction between SNX9 and OCRL may help coordinate actin polymerization at late stage clathrin-coated pits with the turnover of PI 4,5 P2.
We therefore postulate that the down-regulation of these miRNA after birth may help coordinate the activation of negative regulators of growth thereby limiting cardiomyocyte size and possibly heart size relative to body size.
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An additional, related problem may be that there is no central agency for public health in Germany that could help coordinate prevention policies where suitable.
The health organization would help coordinate safety trials.
Want to help coordinate a big event?
Indeed, we cannot exclude the possibility that, together with BRCA2, additional factors may help to coordinate the timely phosphorylation of Rad51 following DNA stress.
Thus, the strength of Myc activity, together with the contribution of other factors may help to coordinate p53 expression levels with the cellular proliferation state in multiple tissue compartments.
As EGF signalling may represent an important mechanism that helps coordinate the process of recovery from lung injury (Polosa et al, 1999; Puddicombe et al, 2000), it is possible that EGFR inhibition will partly reduce the ability of pneumocytes to respond to lung injury.
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