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The term aprotic has been extended recently to include solvents that are unable to lose a proton, although they may have weakly basic properties.
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However, some genes containing exons possibly prone to differential expression may have been weakly expressed and thus undetected in the microarray data.
Some of the selected negative cDNA clones may have produced a weakly positive signal in northern or microarray hybridization experiments due to fairly small stretches of sequence similarity to transcripts present in glucose-grown fungus resulting in cross-hybridization.
"Nonface objects may have certain features that are weakly triggering these face cells," she said.
Furthermore, the fact that high-CpG genes tend to be narrowly expressed (Foret et al. 2009) raises the possibility that high-CpG genes may have the propensity to accumulate weakly deleterious insertion mutations because they are under reduced selective constraints (Duret and Mouchiroud 2000).
The approach that we advocate in this paper suggests that even weakly relevant features may have key biological implications.
For example, two sets of weakly expressed genes may have similar values of codon adaptation index but still possess vastly different codon preferences.
The more weakly interacting codons may have been incorporated later when the translation system evolved to become more efficient and accurate; hence the later amino acids are assigned to the weakly interacting codons.
As some phosphosites are weakly supported and may have resulted from faulty identification, we limited the analysis to proteins that have >5 independent supporting observations from the literature (Additional file 1). Figure 4 illustrates a focused view of 5 representatives from the exceptional cluster-rich proteins.
In this case, 0.39 1.64 (0.37–1.70) substitutions would be expected among the 17 lineages in SW Asia, weakly indicating that HG23 may have originated in SW Asia.
The patchiness that occurred at small scales may have been related to habitat features, but only weakly.
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