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Third, as mentioned above, our experimental protocol may have uncoupled selection pressures on virulence and on latency, allowing the traits to evolve independently and genetically unlinked, at least within the boundaries of the local area around the adaptive peaks.
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As a result, mild uncoupling may have protected the mNSCs from oxidative stress, improving viability and DILP levels.
It has been suggested (albeit controversially) that mtDNA subhaplogroups associated with mild uncoupling may have been selected for their increased thermogenesis in cold climates [21], but may also confer a longevity advantage due to decreased ROS.
It is also possible that HDACIs, drugs known to increase reactive oxygen species levels and the basal level of ERK1/2 activity, may have also caused some form of uncoupling of the CXCR4 receptor from some of its downstream signaling intermediates.
The CM cases reported here also suggest that patients with prior anthracycline exposure may have increased susceptibility to cardiotoxicity from reactive oxygen species generated from proteasome inhibitor induced eNOS uncoupling.
Since exotic species may have escaped from their co-evolved soil enemies (Keane and Crawley 2002; Agrawal et al. 2005), they might be uncoupled from the requirement to associate with a specific belowground microbial community.
Ancestral photosynthetic eukaryotes may have been unable to balance their increasing requirements for ascorbate biosynthesis with maintenance of the redox status within the ER, providing selective pressure to uncouple ascorbate biosynthesis from H2O2 production.
Now that the two concepts have been uncoupled for at least a generation, there is the possibility that Streatfeild's books will start to read like medieval runes.
Thus, the recommendable achievements have been uncoupled with the roadmap of cellulose-degrading enzymes.
This suggests that cox2 duplication may be uncoupled with maleness.
In fact, the movements of the clamps and the mismatch-binding domains may well be uncoupled.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com