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However, diabetes may have tissue specific effects on the expression of NRG1 isoforms.
Recently, restriction fragment length polymorphism (RFLP) analysis indicated that cir genes may have tissue specific patterns of expression [ 30].
It is therefore conceivable that some caleosins may have a more general, 'housekeeping' role in most plant tissues and cell types, whereas other caleosins may have tissue- and cell-type specific roles in signaling and regulation during plant development.
Loss of EAF2 or VHL alone did not significantly affect proliferation in the liver, suggesting that EAF2 and/or VHL may have tissue specific effects in regulation of cell proliferation in the prostate and the liver.
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It is possible that some components may function as general co-chaperones, while others may have tissue-specific functions within the context of the Hsp90/Hsp70 chaperone machinery.
Here, we have demonstrated that mutations in daf-2 did not cause significant changes in whole animal levels of HIF-1 protein or in the expression of two HIF-1 targets that we assayed (Fig. 4), but DAF-2 may have tissue-specific or stage-specific roles in HIF-1 regulation.
Therefore this cross-tissue comparison of expression patterns provides valuable insight into genes that may have tissue-specific functions.
Thus it is not a surprise that ALR is expressed ubiquitously in all organs, and may have tissue-specific functions.
In this aspect, knockout analysis of different class I and class II HDAC proteins indicated that class I HDACs play a role in cell survival and proliferation, whereas class II HDACs may have tissue-specific roles [ 2, 3].
Most recently, it was discovered that the H2B variant H2BE is involved in controlling olfactory gene expression in mice, suggesting that some somatic H2B variants may have tissue-specific roles [ 23].
Others [ 22] analyzed human PPIs in a tissue-specific context, showing that many housekeeping proteins interact with highly tissue-specific proteins, which in turn implies that housekeeping proteins may have tissue-specific roles.
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