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As different transgenic lines often carry the same or similar promoter elements and as coding regions may have sequence homologies, new epigenetic interactions can arise, thus justifying thorough expression testing of stacked transformation events obtained through cross-breeding.
Since like the precursor RNA, cDNA may have sequence homology with regions around a DSB, it raises the possibility that a cDNA reverse transcript might mediate DSBR (Fig. 2).
BLAST analysis suggested that some of these transcripts may have sequence similarities to globins.
EST data are known to contain contaminants and may have sequence error rates as high as 3%.
In so doing, the network can reveal sequences that may have sequence characteristics useful for linking divergent clusters in multiple alignments.
Although it is still possible that some of these transcripts might have been wrongly annotated, actually being C/D box snoRNAs, their distinct Sm protein binding elements and preserved upstream sequence motifs [ 6] might lead to the assumption that a number of C. elegans non-codingtranscripts may have sequence characteristics common to both snRNAs and snoRNAs.
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In some cases, lncRNAs may have sequence-independent functions, whereby the action of their transcription alone may regulate transcription of neighboring genes (a phenomenon called transcriptional interference or promoter occlusion) (Kornienko et al., 2013).
Contexts may have sequences of multiple addressees and sequences of multiple demonstrata.
The genes belonging to CIPs may have sequence-level polymorphisms such as small insertions or deletions (InDels) between indica and japonica varieties.
In addition to the effects of sequence repetition, TE insertions may have sequence-specific phenotypic consequences.
Furthermore, some chimeras may have sequences identical to true alleles, because the latter may originate through historical recombination from other alleles.
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