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Individual differences in single-drug sensitivity constitute therapeutic windows that select for single cell-type; however combinations of drugs may have selectivity that varies from individual agents.
Neurochemical research suggests that etizolam may have selectivity for the subpopulation of Y-aminobutyric acid type A receptors associated with anxiety (ie, α1, β2, γ2).
These results suggested that the increasing accumulation of class I ZmNAS genes in roots under changing environmental metal status may have selectivity for Fe and Zn.
Our study uncovers a set of unexpected observations regarding the substrate specificity of LTA4H, and predicts that this enzyme may have selectivity for post-translationally modified N-terminal amino acids.
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This supports our finding that a more functional approach may have higher selectivity than expression-based methods.
Some judgment was exercised in this regard, as a given polycation may have variable selectivity depending on the tested organisms.
It is apparent from the tables that the discrimination performance is non-symmetric, i.e. a Random Forest trained on ligand 1 may have poor selectivity for ligand 2 but one trained on ligand 2 may be good at rejecting ligand 1 binding sites in favor of the correct ligand 2 sites.
As shown in Figure 1d, we found that the sensitivity of the NBECs to ABL-N was much lower, with ABL-N only having a significant effect on the viability (28% reduction, P <0.05) of the NBECs following 24 hours of treatment at the 40 μM dose, suggesting that ABL-N may have potential selectivity toward tumor cells.
The EGFR inhibitor lapatinib was one of the first nearly monospecific kinase inhibitors [39]; others may have much broader selectivity profiles [40].
These two catalytic domains may have different substrate selectivity.
RNase HI and RNase HII may have similar substrate selectivity.
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