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Such gain-of-function appears to be a defining feature of typical absence seizures, and may have pathological consequences in patients deficient for SSADH.
Because CHIK virus-infected cells have been observed three to four months after the acute crisis, we hypothesize that infection of precursor cells may have pathological consequences on long-term muscle physiology in patients.
Thus, it is expected that evolutionary fixation of mutations in MOMP B-cell antigenic regions may have pathological consequences at the concertedly humoral and cellular immune responses, which may contribute to chlamydial recurrence or persistence, as previously demonstrated for several virus [37].
TBRII gene and protein expression defect in MSC derived from SSc patients may have pathological significance.
Taken together, these data indicate that variants in this highly conserved domain may have pathological consequences, which might contribute to human disease.
Acetic and glycolic acids are unlikely to have any pathological effects, formic acid is metabolized rapidly, but even so its generation by glycation in the eyes may have pathological consequences due to its high ocular toxicity.
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Third, because the presence of a UIP pattern on HRCT had low sensitivity and negative predictive value for the detection of pathologic UIP, it was likely that some patients with a non-UIP pattern on HRCT may have had pathological UIP.
As some of these patients may indeed have pathological stage I disease, close surveillance or staging RPLND is recommended.
However, a retrospective review of cases diagnosed as intestinal spirochetosis revealed that the presence of Spirochetes in the gastrointestinal biopsies is often asymptomatic and may not have pathological significance (Carr et al., 2010).
Since α-synucleinopathy was reported in this case, although little is known about the relationship between α-synuclein and tau in AD, pathological processes involving α-synuclein may have influenced pathological progression in this patient.
"I noticed that Leonardo da Vinci's image of a man had a feature that may have been pathological.
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