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They investigated whether these people may have mutations in 29 genes that code for DNA-damage-repair proteins.
A number of transgenic plants that may have mutations in target 1/2 in Nipponbare background were obtained.
Among strains of A. cellulolyticus, CF-2612 has the highest cellulase productivity (Fang et al. 2009), but it underwent random mutagenesis and may have mutations at every site as well as cellulase related genes.
However what is perhaps even more interesting than the 11% of men who had substantial responses, is the researchers have reason to believe that many of these tumors may have mutations in genes which control vital cellular processes that maintain the genome, called DNA repair.
One possible explanation for this finding is that the Lmna−/− cells used for these studies have been immortalized and may have mutations and/or altered expression in other genes that promote pRB destabilization (e.g. MDM2).
Patients without detectable mutations may have mutations in introns or in the regulatory or untranslated regions.
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Colon cancers often have KRAS2 mutations and, if not KRAS2 mutations, may have BRAF mutations.
The SAMP3 strain may have additional mutations besides the Gja3 p.S405P mutation that are responsible for cataract.
Many women, who have a family history of breast and/or ovarian cancer and do not have a BRCA1 or BRCA2 mutation, may have a mutation in undiscovered genes.
During evolutionary processes, nuclear genomes may have accumulated mutations, while organelle genomes accumulated compensatory mutations and vice versa.
A woman carrying the pathogenic mutation may thus have mutation-free embryos, advocating PGD as an appropriate procedure for preventing recurrence of affected offspring in carriers, at least in the mutant load range reported in this study.
More suggestions(15)
may identify mutations
may acquire mutations
may compare mutations
may buffer mutations
may discover mutations
may include mutations
may have advantages
may indicate mutations
may find mutations
may carry mutations
may precede mutations
may induce mutations
may introduce mutations
may suggest mutations
may tolerate mutations
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