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In fact, critically ill patients with sepsis may have late immunodepression with lymphocytic apoptosis, lymphocytopenia, T-cell anergy, promoting viral reactivation [ 23, 24].
In light of these observations, it seems obvious that blocking RAAS and consequently, interfering pathways involved in early organ damage may have late beneficial vascular effect.
Patients with a low CD4 cell count (<300 cells/µl) may represent a population who may have late HIV diagnosis, with very low nadir CD4 and immune restoration failure due to inability to reconstitute depleted T cell populations despite virologic suppression.
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Cardiotoxicity outcomes occurred early and on treatment [ 24, 27, 28]; late and off treatment [ 26, 29, 30], and some may have occurred late and off treatment [ 25, 31].
But they may have been late by some nine months.
I may have started late, but since I discovered it, I haven't stopped.
"I may have been late sometimes but they all got paid".
As with Williams, his chance may have come late, but he seized it greedily.
It may have come late but Sergio Agüero is a cool guy and he will score".
Clinton may have come late to Flint, but she came strong.
"They may have started late, but it's better than never".
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CEO of Professional Science Editing for Scientists @ prosciediting.com